Diabetes is one of the most common diseases in the modern world. It is the leading cause of poor vision and blindness. Diabetic Macular Edema (DME), a complication of diabetes, contributes greatly to this low vision or blindness. It affects up to 50% of people diagnosed with diabetes.

What Is Diabetic Macular Edema?

Diabetic Macular Edema is a sight-threatening condition that affects the retina of the eye. The retina is a light sensing thin layer of nerve cells located in the back of the eye. The central part of the retina is called ‘macula’ and centre of the macula is called the ‘fovea’ which is responsible for giving us fine, detailed and sharpest far and near vision.  Diabetic Macular Edema is characterised by the leakage of fluid from the damaged retinal vessels into the retina. As the eye condition worsens over a period of time, it gets difficult to focus clearly.

Diabetic macular oedem

Figure 1. Diabetic Macular oedema

What Causes Diabetic Macular Edema?

A patient with diabetic retinopathy develops this serious sight threatening condition. In some diabetic patients, the level of blood glucose is very high which affects the fine retinal meshwork of blood vessels and it gets leaky or damaged. This eventually affects the supply of nutrients and oxygen to the macular region of the eye.

The damaged blood vessels of the retina allow blood or fluid from the bloodstream to leak into the thin retinal layer. Due to fluid accumulation, the layer becomes water or fluid-logged and fails to function properly. If left untreated, the blood vessels start to build pressure and cause leakage of fluid in the centre of the macula causing diabetic macular oedema. This results in macular swelling, vision impairment or blindness.  This serious condition can occur at any stage of diabetic retinopathy, but it generally occurs as the disease progresses. Also, abnormal kidney function as a result of diabetic nephropathy can also increase the chances of diabetic macular oedema.

Types of Diabetic Macular Edema

It is divided into the following forms:

  • Centre-involving DME: In this form, the fovea and/ or the immediate area around the central macular region is affected.
  • Non-centre involving DME: It is the extra-foveal diabetic macular oedema.
  • Ischaemic maculopathy: In this type, the meshwork of blood vessels of the macular area shuts down because of the high blood glucose levels in diabetic patients.
  • Focal DME: It occurs due to the leakage of fluid resulting from abnormalities in the retinal blood vessels.
  • Diffuse DME: When there is widening or swelling of the retinal capillaries, diffuse diabetic macular oedema occurs.

Symptoms of Diabetic Macular Oedema

In the early stages of diabetes, people do not notice any changes in the vision. The eyesight remains good if the retinal damage causes only small bulges in the blood vessels. In some cases, the blood vessels in or around the macula get damaged, or sometimes, there is a sudden leakage of fluid or bleeding into the macula. In such patients, the eyesight worsens dramatically.

Hence, it is best to look out for certain signs and symptoms related to diabetic macular oedema:

  • Dark Spots
  • Smudge in vision
  • Gaps in the vision
  • Fading of colours
  • Subjects or objects might appear to change their color, size, shape or disappear.
  • Difficulty in reading
  • Distortion of vision

diabetes, diabetic retinopathy

Figure 2.

Factors that increase the risk of Diabetic Macular Edema

There is an increased risk of diabetic macular oedema with:

  • Type of diabetes
  • Glucose levels that are maintained poor over a long period of time
  • Living with diabetes for an increased length of time
  • Fluid retention
  • High blood pressure
  • Kidney disease
  • Hyperlipidemia
  • Pregnancy

Diagnosis

Diabetic Macular Edema is generally detected during a comprehensive eye exam. Your ophthalmologist or eye doctor can carry out any of these tests on dilated eyes for this:

  • Visual acuity testing
  • Tonometry
  • Pupil dilation
  • Optical coherence tomography
  • Fluorescein angiography, etc.

diabetic macular oedema

Figure 3. Optical Tomography Scan of a patient with diabetic macular oedema showing fluid collection in the retina.

Treatment

The treatment for diabetic macular oedema differs as per its type and whether fovea is involved or not. Generally, your ophthalmologist will prescribe some eye drops and intravitreal injections of anti-VEGF or steroid, if the condition involves the fovea. If the eye condition is extrafoveal, the treatment involves laser procedures to the abnormal blood vessels to stop the leakage in the macula. It should be noted that treatments cannot perfectly restore your eyesight if there is significant damage to the macula, especially if there is ischaemia. But, the treatment can slow down the damage rate and thus, preserve your eyesight for a longer period of time.

As diabetes is usually a lifelong condition, it is essential to maintain a healthy lifestyle. Also, stable blood sugars are extremely important for a healthy vision. Also, you should monitor your blood sugar levels, blood pressure, and cholesterol to avoid damage to the eyes.

Dr. Raja Rami Reddy P

Dr. Raja Rami Reddy P

MD FRCS (Glasg), Chief Retina Surgeon, Founder & Medical Director at Neoretina
Dr. Reddy is a renowned specialist in retinal surgery with more than 20 years’ experience in the field. He is the Founder, Director and Chief Retinal Surgeon at NEORETINA Eyecare Institute, Hyderabad, which is a foremost referral centre for diseases of the Retina. His areas of expertise include Surgical Retina especially complicated vitreo-retinal surgeries for retinal detachment, vitreous hemorrhage, advanced diabetic retinopathy, macular holes and epiretinal membranes. He studied MBBS and MD at the prestigious All India Institute of Medical Sciences, New Delhi and was a Specialist Registrar at the Vitreo-Retina Department of the reputed Dr. Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi. He is a member of the American Society of Retinal Surgeons and is an active member of the state and national academic societies.
Dr. Raja Rami Reddy P

Latest posts by Dr. Raja Rami Reddy P (see all)